Neurological Diseases and Relation of TRP Channels by Yener Yazğan in Online Journal of Neurology and Brain Disorders in Lupine Publishers
Is currently used as a comprehensive definition covering “brain disorders”, neurological diseases and mental disorders. While
schizophrenia, depression, panic disorder, drug addiction and insomnia
are referred to as “mental disorders”, Epilepsy, Alzheimer,
Parkinson, Huntington’s disease (HD) and multiple sclerosis are
considered as “neurological disorders”. Current therapies of these
very common diseases require continuous drug use and at the same time
cause many different side effects. Therefore preclinical
and clinical investigations for new treatment approaches are on the
rise. Especially the identification of the molecular basis of these
diseases is the focus of researches.
Examination of transient receptor potential (TRP) channels is at an
early stage in the investigation of the molecular principle of
these diseases, but clear results regarding the efficacy of substances
activating or inhibiting these channels have not been obtained.
Some diseases have been based on mutations of TRP channels. However,
only a few TRP channelopathies, have been conclusively
identified so far [1]. Investigation of TRP channels in psychiatric disorders will contribute to a better understanding of the etiology
of psychiatric disorders and the development of new pharmacological treatments.
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